What those two said.. depending what you want to do with the file. If you want to post it online or watch by yourself use h264 (pick it directly from formats, or as a codec in quicktime settings) - it's tiny and pretty good quality, I think that's what youtube and vimeo is using.
If you need a HQ version for some reason I'd still use Quicktime with animation codec - that's uncompressed, so very good quality but big file.
Last edited by nov2011; 28-02-2012 at 02:40 AM.